発表論文
2017年
Kyomoto M, Moro T, Yamane S, Takatori Y, Tanaka S, Ishihara K: A hydrated phospholipid polymer-grafted layer prevents lipid-related oxidative degradation of cross-linked polyethylene. Biomaterials 112: 122-132, 2017.
Oshima H, Tanaka S, Takatori Y, Tanaka T, Ishikura H, Moro T: Clinical and radiographic outcomes of total hip arthroplasty with a specific liner in small Asian patients: Influence of patient-related, implant-related, and surgical factors on femoral head penetration. J Arthroplasty (in press).
Yamane S, Kyomoto M, Moro T, Hashimoto M, Takatori Y, Tanaka S, Ishihara K: Wear resistance of poly(2-methacryloyloxyethyl phosphorylcholine)-grafted carbon fiber reinforced poly(ether ether ketone) liners against metal and ceramic femoral heads. J Biomed Mater Res B Appl Biomater (in press).
Saiga K, Kyomoto M, Watanabe K, Taketomi S, Kadono Y, Takatori Y, Tanaka S, Ishihara K, Moro T: Effects of material thickness and surface modification of cross-linked polyethylene with poly(2-methacryloyloxyetheyl phosphorylcholine) on its deformation behavior, wear resistance and durability under repetitive impact-to-sliding motion. Biotribology (in press).
2016年
Yamane S, Kyomoto M, Moro T, Watanabe K, Hashimoto M, Takatori Y, Tanaka S, Ishihara K: Effects of extra irradiation on surface and bulk properties of PMPC-grafted cross-linked polyethylene. J Biomed Mater Res A 104(1): 37-47, 2016.
Uehara S, Yarimitsu S, Moro T, Kyomoto M, Watanabe K, Tanaka S, Ishihara K, Murakami T: Evaluation of wear suppression for phospholipid polymer-grafted ultra-high molecular weight polyethylene at concentrated contact. Tribol Int 101: 264-272, 2016.
Moro T, Takatori Y, Tanaka S, Ishihara K, Oda H, Kim YT, Umeyama T, Fukatani E, Ito H, Kyomoto M, Oshima H, Tanaka T, Kawaguchi H, Nakamura K: Clinical safety and wear resistance of the biocompatible phospholipid polymer-grafted highly cross-linked polyethylene liner. J Orthop Res (in press).
Watanabe K, Moro T, Kyomoto M, Saiga K, Taketomi S, Kadono Y, Takatori Y, Tanaka S, Ishihara K: The effects of presence of backside screw hole on biotribological behavior of phospholipid polymer-grafted cross-linked polyethylene. J Biomed Mater Res B Appl Biomater (in press).
2015年
Oka T, Abawi CF, Sugita N, Chikuda H, Sugita S, Tanaka T, Oshima H, Moro T, Tanaka S, Mitsuishi M: Hand-held bone-cutting tool with autonomous penetration detection for spinal surgery. IEEE/ASME Trans Mechatronics 20(6): 3018-3027, 2015.
Kyomoto M, Shobuike T, Moro T, Yamane S, Takatori Y, Tanaka S, Miyamoto H, Ishihara K: Prevention of bacterial adhesion and biofilm formation on a vitamin E-blended, cross-linked polyethylene surface with a poly(2-methacryloyloxyethyl phosphorylcholine) layer. Acta Biomater 24(15): 24-34, 2015.
Yarimitsu S, Moro T, Kyomoto M, Watanabe K, Tanaka S, Ishihara K, Murakami T: Influences of dehydration and rehydration on the lubrication properties of phospholipid polymer-grafted cross-linked polyethylene. Proc Inst Mech Eng H 229(7): 506-514, 2015.
Watanabe K, Kyomoto M, Saiga K, Taketomi S, Inui H, Kadono Y, Takatori Y, Tanaka S, Ishihara K, Moro T: Effects of surface modification and bulk geometry on the biotribological behavior of cross-linked polyethylene: Wear testing and finite element analysis. Biomed Res Int 2015: 435432, 2015.
Moro T, Takatori Y, Kyomoto M, Ishihara K, Kawaguchi H, Hashimoto M, Tanaka T, Oshima H, Tanaka S: Wear resistance of the biocompatible phospholipid polymer-grafted highly cross-linked polyethylene liner against larger femoral head. J Orthop Res 33(7): 1103-1110, 2015.
Kyomoto M, Moro T, Takatori Y, Tanaka S, Ishihara K: Multidirectional wear and impact-to-wear tests of phospholipid-polymer-grafted and vitamin E-blended crosslinked polyethylene: a pilot study. Clin Orthop Relat Res 473(3): 942-951, 2015.
Takatori Y, Moro T, Ishihara K, Kamogawa M, Oda H, Umeyama T, Kim YT, Ito H, Kyomoto M, Tanaka T, Kawaguchi H, Tanaka S: Clinical and radiographic outcomes of total hip replacement with poly(2-methacryloyloxyethyl phosphorylcholine)-grafted highly cross-linked polyethylene liners: Three-year results of a prospective consecutive series. Mod Rheumatol 25(2): 286-291, 2015.
Ito H, Takatori Y, Moro T, Oshima H, Oka H, Tanaka S: Total hip arthroplasty after rotational acetabular osteotomy. J Arthroplasty 30(3): 403-406, 2015.
2014年
Kyomoto M, Moro T, Yamane S, Watanabe K, Takatori Y, Tanaka S, Ishihara K: Smart PEEK modified by self-initiated surface graft polymerization for orthopedic bearings. Reconstructive Review 4(3): 36-45, 2014.
Kyomoto M, Moro T, Yamane S, Watanabe K, Hashimoto M, Takatori Y, Tanaka S, Ishihara K: Poly(2-methacryloyloxyethyl phosphorylcholine) grafting and vitamin E blending for high wear resistance and oxidative stability of orthopedic bearings. Biomaterials 35: 6677-6686, 2014.
Kyomoto M, Moro T, Yamane S, Hashimoto M, Takatori Y, Ishihara K: Effect of UV-irradiation intensity on graft polymerization of 2-methacryloyloxyethyl phosphorylcholine on orthopedic bearing substrate. J Biomed Mater Res A 102A: 3012-3023, 2014.
Moro T, Takatori Y, Kyomoto M, Ishihara K, Hashimoto M, Ito H, Tanaka T, Oshima H, Tanaka S, Kawaguchi H: Long-term hip simulator testing of the artificial hip joint bearing surface grafted with biocompatible phospholipid polymer. J Orthop Res 32(3): 369-376, 2014.
Moro T, Kyomoto M, Ishihara K, Saiga K, Hashimoto M, Tanaka S, Ito H, Tanaka T, Oshima H, Kawaguchi H, Takatori Y: Grafting of poly (2-methacryloyloxyethyl phosphorylcholine) on polyethylene liner in artificial hip joints reduces production of wear particles. J Mechan Behav Biomed Mater 34: 100-106, 2014.
Sugano N, Iida H, Akiyama H, Takatori Y, Nagoya S, Hasegawa M, Kabata T, Hachiya Y, Yasunaga Y: Nationwide investigation into adverse tissue reactions to metal debris after metal-on-metal total hip arthroplasty in Japan. J Orthop Sci 19(1): 85-89, 2014.
Okano K, Jingushi S, Ohfuji S, Sofue M, Hirota Y, Itoman M, Hamada Y, Shindo H, Takatori Y, Yamada H, Yasunaga Y, Ito H, Mori S, Owan I, Ohashi H, Yamaguchi K: Relationship of acetabular dysplasia in females with osteoarthritis of the hip to the distance between both anterior superior iliac spines. Med Sci Monit 20: 116-122, 2014.
2013年
Kyomoto M, Moro T, Yamane S, Hashimoto M, Takatori Y, Ishihara K: Poly(ether-ether-ketone) orthopedic bearing surface modified by self-initiated surface grafting of poly(2-methacryloyloxyethyl phosphorylcholine). Biomaterials 34: 7829-7839, 2013.
Takatori Y, Moro T, Kamogawa M, Oda H, Morimoto S, Umeyama T, Minami M, Sugimoto H, Nakamura S, Karita T, Ito H, Kim J, Koyama Y, Kawaguchi H, Nakamura K: The poly (2-methacryloyloxyethyl phosphorylcholine)-grafted highly cross-linked polyethylene liner in primary total hip replacement -One-year results of a prospective cohort study. J Artif Organs 16: 170-175, 2013.
2012年
Kyomoto M, Moro T, Saiga K, Hashimoto M, Ito H, Kawaguchi H, Takatori Y, Ishihara K: Biomimetic hydration lubrication with various polyelectrolyte layers on cross-linked polyethylene orthopedic bearing materials. Biomaterials 33(18): 4451-4459, 2012.
2011年
Kyomoto M, Moro T, Takatori Y, Kawaguchi H, Ishihara K: Cartilage-mimicking, high-density brush structure improves wear resistance of crosslinked polyethylene: a pilot study. Clin Orthop Relat Res 469: 2327-2336, 2011.
Jingushi S, Ohfuji S, Sofue M, Hirota Y, Itoman M, Matsumoto T, Hamada Y, Shindo H, Takatori Y, Yamada H, Yasunaga Y, Ito H, Mori S, Owan I, Fujii G, Ohashi H, Iwamoto Y, Miyanishi K, Iga T, Takahira N, Sugimori T, Sugiyama H, Okano K, Karita T, Ando K, Hamaki T, Hirayama T, Iwata K, Nakasone S, Matsuura M, Mawatari T: Osteoarthritis hip joints in Japan: involvement of acetabular dysplasia. J Orthop Sci 16: 156-164, 2011.
Ishiyama N, Moro T, Ohe T, Miura T, Ishihara K, Konno T, Ohyama T, Yoshikawa M, Kyomoto M, Saito T, Nakamura K, Kawaguchi H: Reduction of peritendinous adhesions by hydrogel containing biocompatible phospholipid polymer MPC for tendon repair. J Bone Joint Surg Am 19: 142-149, 2011.
2010年
Moro T, Takatori Y, Kyomoto M, Ishihara K, Saiga K, Nakamura K, Kawaguchi H: Surface grafting of biocompatible phospholipid polymer MPC provides wear resistance of tibial polyethylene insert in artificial knee joints. Osteoarthritis Cartilage 18(9): 1174-82, 2010.
Takatori Y, Ito K, Sofue M, Hirota Y, Itoman M, Matsumoto T, Hamada Y, Shindo H, Yamada H, Yasunaga Y, Ito H, Mori S, Owan I, Fujii G, Ohashi H, Mawatari T, Iga T, Takahira N, Sugimori T, Sugiyama H, Okano K, Karita T, Ando K, Hamaki T, Hirayama T, Iwata K, Matsuura M, Jingushi S: Analysis of interobserver reliability for radiographic staging of coxarthrosis and indexes of acetabular dysplasia: a preliminary study. J Orthop Sci 15: 14-19, 2010.
Kyomoto M, Moro T, Takatori Y, Kawaguchi H, Nakamura K, Ishihara K: Self-initiated surface grafting with poly(2-methacryloyloxyethyl phosphorylcholine) on poly(ether-ether-ketone). Biomaterials 31: 1017-1024, 2010.
Kyomoto M, Moro T, Saiga KI, Miyaji F, Kawaguchi H, Takatori Y, Nakamura K, Ishihara K: Lubricity and stability of poly(2-methacryloyloxyethyl phosphorylcholine) polymer layer on Co-Cr-Mo surface for hemi-arthroplasty to prevent degeneration of articular cartilage. Biomaterials 31: 658-668, 2010.
Ishiyama N, Moro T, Ishihara K, Ohe T, Miura T, Konno T, Ohyama T, Kimura M, Kyomoto M, Nakamura K, Kawaguchi H: The prevention of peritendinous adhesions by a phospholipid polymer hydrogel formed in situ by spontaneous intermolecular interactions. Biomaterials 31: 4009-4016, 2010.
Liu G, Iwata K, Ogasawara T, Watanabe J, Fukazawa K, Ishihara K, Asawa Y, Fujihara Y, Chung UL, Moro T, Takatori Y, Takato T, Nakamura K, Kawaguchi H, Hoshi K: Selection of highly osteogenic and chondrogenic cells from bone marrow stromal cells in biocompatible polymer-coated plates. J Biomed Mater Res A 92: 1273-1282, 2010.
Jingushi S, Ohfuji S, Sofue M, Hirota Y, Itoman M, Matsumoto T, Hamada Y, Shindo H, Takatori Y, Yamada H, Yasunaga Y, Ito H, Mori S, Owan I, Fujii G, Ohashi H, Iwamoto Y, Miyanishi K, Iga T, Takahira N, Sugimori T, Sugiyama H, Okano K, Karita T, Ando K, Hamaki T, Hirayama T, Iwata K, Nakasone S, Matsuura M, Mawatari T: Multiinstitutional epidemiological study regarding osteoarthritis of the hip in Japan. J Orthop Sci 15: 626-631, 2010.
2009年
Kyomoto M, Moro T, Miyaji F, Hashimoto M, Kawaguchi H, Takatori Y, Nakamura K, Ishihara K: Effects of mobility/immobility of surface modification by 2-methacryloyloxyethyl phosphorylcholine polymer on the durability of polyethylene for artificial joints. J Biomed Mater Res A 90: 362-371, 2009.
Moro T, Kawaguchi H, Ishihara K, Kyomoto M, Karita T, Ito H, Nakamura K, Takatori Y: Wear resistance of artificial hip joints with poly(2-methacryloyloxyethyl phosphorylcholine) grafted polyethylene: Comparisons with the effect of polyethylene cross-linking and ceramic femoral heads. Biomaterials 30: 2995-3001, 2009.
Kyomoto M, Moro T, Iwasaki Y, Miyaji F, Kawaguchi H, Takatori Y, Nakamura K, Ishihara K: Superlubricious surface mimicking articular cartilage by grafting poly(2-methacryloyloxyethyl phosphorylcholine) on orthopaedic metal bearings. J Biomed Mater Res A 91: 730-741, 2009.
Kyomoto M, Ishihara K: Self-initiated surface graft polymerization of 2-methacryloyloxyethyl phosphorylcholine on poly(ether-ether-ketone) by photo-irradiation. ACS Applied Materials & Interfaces 1: 537-542, 2009.
Haga N, Karita T, Amao R, Kanamori Y, Takatori Y: Successful ambulation by surgical conversion in a complex form of epigastric heteropagus. J Pediatr Orthop B 18(6): 394-396, 2009.
2008年
Kyomoto M, Moro T, Miyaji F, Hashimoto M, Kawaguchi H, Takatori Y, Nakamura K, Ishihara K: Effect of 2-methacryloyloxyethyl phosphorylcholine concentration on photo-induced graft polymerization of polyethylene in reducing the wear of orthopaedic bearing surface. J Biomed Mater Res A 86: 439-447, 2008.
Kyomoto M, Moro T, Miyaji F, Konno T, Hashimoto M, Kawaguchi H, Takatori Y, Nakamura K, Ishihara K: Enhanced wear resistance of orthopedic bearing due to the cross-linking of poly(MPC) graft chains induced by gamma-ray irradiation. J Biomed Mater Res B Appl Biomater 84: 320-327, 2008.
Koyama Y, Miyashita M, Irie S, Yamamoto M, Karita T, Moro T, Takatori Y, Kazuma K: A study of disease management activities of hip osteoarthritis patients under conservative treatment. J Orthop Nurs 12: 75-83, 2008.
日本語総説
京本政之, 茂呂徹, 石原一彦:長寿命型人工関節の技術とその開発. 化学工学 79(5): 375-379, 2015.
増田裕也, 茂呂徹: 整形外科領域におけるバイオマテリアル ー人工関節についてー. バイオマテリアル 32(4): 327-329, 2014.
橋本雅美, 京本政之, 茂呂徹, 石原一彦: 長寿命型人工股関節の開発と実用化. Fine Ceramics Report 31 (4): 120-124, 2013.
茂呂徹, 京本政之, 高取吉雄: 人工股関節ポリエチレンライナーのMPC処理. Bone Joint Nerve 10 (3): 417-424、2013.
京本政之, 難波良太, 山脇昇: 新規バイオマテリアル設計を基盤とする長寿命型人工股関節の開発. バイオマテリアル 31 (1): 17-25, 2013.
京本政之, 茂呂徹, 石原一彦: 生体親和性ポリマーを活用した長寿命人工股関節. 産学官連携ジャーナル 9 (9): 22-24, 2013.
京本政之, 茂呂徹, 石原一彦: バイオミメティック技術“Aquala®”を基盤とした人工股関節の開発と実用化. Fine Ceramics Report 30 (2): 44-8, 2012.
茂呂徹, 石原一彦, 高取吉雄, 川口浩, 中村耕三, 京本政之, 山脇昇, 興松英昭: 表面処理技術Aquala®テクノロジーにより処理された人工股関節寛骨臼コンポーネント(商品名:Aquala®ライナー),およびそれを搭載した人工股関節. 人工臓器 41 (1): 49-50, 2012.
京本政之: 生体の構造・機能模倣がもたらす長寿命人工関節. バイオマテリアル 28 (3): 177-178, 2010.
京本政之, 茂呂徹, 石原一彦: MPCポリマー処理架橋ポリエチレン人工関節の実用化. 人工臓器 40 (1): 57-61, 2011.
茂呂徹: 生体親和性リン脂質ポリマーのナノ表面処理による新しい人工股関節. 雑誌整形外科 62 (8): 861-866, 2011.
茂呂徹: ナノテクノロジーを応用した新しい人工股関節の開発. マルホ整形外科セミナー 209: 15-17, 2011.
京本政之, 茂呂徹, 石原一彦: 関節軟骨を模倣した高潤滑摺動表面がもたらす人工関節の長寿命化. 表面科学 32 (9): 557-562, 2011.
高取吉雄: 跛行.pp257-259.金澤一郎,永井良三総編集. 今日の診断指針(改訂第6版). 医学書院,東京,2010.
茂呂徹, 高取吉雄, 石原一彦, 京本政之, 中村耕三, 川口浩: 人工臓器 最近の進歩 人工関節. 人工臓器 38 (3): 152-154, 2009.
茂呂徹, 高取吉雄, 石原一彦, 京本政之, 中村耕三, 川口浩: 変形関節症 Up-to-date 長寿命型人工関節の開発. Clin Calcium 19 (11): 1629-37, 2009.
日本語書籍
茂呂徹: 大腿骨頭すべり症. 今日の診断指針(第7版) 1560-1561, 医学書院, 2015.
茂呂徹: バイオマテリアル. 南山堂医学大事典(第20版) 1918, 南山堂, 2015.
茂呂徹: 生体適合性制御と要求特性掌握から実践する高分子バイオマテリアルの設計・開発戦略 第5編医療における最先端バイオマテリアル 第11部医療機器開発現場にみる高分子材料への要求特性とニーズ 5.~医療機器開発現場より~生涯入れ換える必要のない人工関節を目指して 399-400, サイエンス&テクノロジー, 2014.
京本政之: 未来型人工関節を目指して―その歴史から将来展望まで― 第7章 表面処理技術 第2節 組織適合性の付与のための表面処理方法. 第8項 MPCポリマー処理技術Aqualaの実用化 319-323, 日本医学館, 2013.
京本政之: アンチ・エイジングシリーズ3 骨研究最前線 第4編骨のアンチエイジングとデバイス開発 第2章 骨疾患に伴うQOL 向上のためのデバイス開発. 第2節MPCポリマー処理を用いた長寿命型人工股関節の開発 355-66, エヌ・ティー・エヌ, 2013.
茂呂徹: 先端バイオマテリアルハンドブック 第5編医療における最先端バイオマテリアル 第1章人工臓器用バイオマテリアル. 2節整形外科 216-20, エヌ・ティー・エヌ, 2012.
英語書籍
Kyomoto M, Moro T, Ishihara K: Polymers for artificial joints. Polymeric Biomaterials. Structure and Function (Editor Dumitriu S), CRS press, 851-883, 2013.